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Index > Protein center > Dmp1(Gene name) > Mouse
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  • Dmp1 (Gene name),
  • Dentin matrix acidic phosphoprotein 1 (Protein name ),  DMP1_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    Dmp1(Dmp);
    Protein name:
    Dentin matrix acidic phosphoprotein 1(DMP-1;Dentin matrix protein 1);
    Alternative:
    AG1;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with importin alpha.
    Function:
    May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite.
    Subcellular Location:
    Nucleus Cytoplasm Secreted extracellular space extracellular matrix In proliferating preosteoblasts it is nuclear, during early maturation stage is cytoplasmic and in mature osteoblast localizes in the mineralizated matrix. Export from the nucleus of differentiating osteoblast is triggered by the release of calcium from intracellular stores followed by a massive influx of this pool of calcium into the nucleus.
    Protein Attributes:
    Sequence length:
    503
    Sequence:
    50:
    MKTVILLVFL | WGLSCALPVA | RYHNTESESS | EERTGDLAGS | PPPPTNSESS | 
    100:
    EESQASPEGQ | ANSDHTDSSE | SGEELGYDRG | QYRPAGGLSK | STGTGADKED | 
    150:
    DEDDSGDDTF | GDEDNDLGPE | EGQWGGPSKL | DSDEDSTDTT | QSSEDSTSQE | 
    200:
    NSAQDTPSDS | KDHDSEDEAD | SRPEAGDSTQ | DSESEEQRVG | GGSEGESSHG | 
    250:
    DGSEFDDEGM | QSDDPESTRS | DRGHARMSSA | GIRSEESKGD | HEPTSTQDSD | 
    300:
    DSQSVEFSSR | KSFRRSHVSE | EDYRGELTDS | NSRETQSDST | EDTASKEESR | 
    350:
    SESQEDTAES | QSQEDSPEGQ | DPSSESSEEA | GEPSQESSSE | SQEGVTSESR | 
    400:
    GDNPDNTSQA | GDQEDSESSE | EDSLNTFSSS | ESQSTEEQAD | SESNESLSLS | 
    450:
    EESQESAQDG | DSSSQEGLQS | QSASTESRSQ | ESQSEQDSRS | EEDSDSQDSS | 
    500:
    RSKEESNSTG | SASSSEEDIR | PKNMEADSRK | LIVDAYHNKP | IGDQDDNDCQ | 
    503:
    DGY
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    KEGG:
    UniGene:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse DMP-1
    Cat.:
    E2078r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Mouse DMP-1
    Cat.:
    E2078h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse DMP-1
    Cat.:
    E2078m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse DMP-1
    Cat.:
    E2078b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse DMP-1
    Cat.:
    U2078m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse DMP-1
    Cat.:
    U2078h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse DMP-1
    Cat.:
    U2078r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse DMP-1
    Cat.:
    U2078b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse DMP-1
    Cat.:
    P2078Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse DMP-1
    Polyclonal Antibody for Mouse DMP-1
    Cat.:
    P2078Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse DMP-1
    Cat.:
    P2078Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse DMP-1
    Monoclonal Antibody for Mouse DMP-1
    Monoclonal Antibody for Mouse DMP-1
    Monoclonal Antibody for Mouse DMP-1
    Protein for Mouse DMP-1
    Protein for Mouse DMP-1
    Protein for Mouse DMP-1
    Protein for Mouse DMP-1

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    References
    1. 1.
      "Identification of a novel isoform of mouse dentin matrix protein 1: spatial expression in mineralized tissues."
      McDougall M. , Gu T.T. , Luan X. , Simmons D. , Chen J.
      J. Bone Miner. Res.13:422-431(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: Swiss Webster.
      tissue: Molar.
    2. 2.
      "Study of murine Dmp-1 gene function and regulation."
      Feng J.Q. , Traianedes K. , Luan X. , McDougall M.
      Submitted (1999-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      strain: 129/SvJ.
      tissue: Spleen.
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Head.
      tissue: Inner ear.
    4. 4.
      Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
      Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism."
      Feng J.Q. , Ward L.M. , Liu S. , Lu Y. , Xie Y. , Yuan B. , Yu X. , Rauch F. , Davis S.I. , Zhang S. , Rios H. , Drezner M.K. , Quarles L.D. , Bonewald L.F. , White K.E.
      Nat. Genet.38:1310-1315(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
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