Protein name:
Dentin matrix acidic phosphoprotein 1 (DMP-1;Dentin matrix protein 1) ;
Alternative:
AG1 ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with importin alpha.
Function:
May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite.
Subcellular Location:
Nucleus
Cytoplasm
Secreted
extracellular space
extracellular matrix
In proliferating preosteoblasts it is nuclear, during early maturation stage is cytoplasmic and in mature osteoblast localizes in the mineralizated matrix. Export from the nucleus of differentiating osteoblast is triggered by the release of calcium from intracellular stores followed by a massive influx of this pool of calcium into the nucleus.
Protein Attributes:
50:
MKTVILLVFL | WGLSCALPVA | RYHNTESESS | EERTGDLAGS | PPPPTNSESS |
100:
EESQASPEGQ | ANSDHTDSSE | SGEELGYDRG | QYRPAGGLSK | STGTGADKED |
150:
DEDDSGDDTF | GDEDNDLGPE | EGQWGGPSKL | DSDEDSTDTT | QSSEDSTSQE |
200:
NSAQDTPSDS | KDHDSEDEAD | SRPEAGDSTQ | DSESEEQRVG | GGSEGESSHG |
250:
DGSEFDDEGM | QSDDPESTRS | DRGHARMSSA | GIRSEESKGD | HEPTSTQDSD |
300:
DSQSVEFSSR | KSFRRSHVSE | EDYRGELTDS | NSRETQSDST | EDTASKEESR |
350:
SESQEDTAES | QSQEDSPEGQ | DPSSESSEEA | GEPSQESSSE | SQEGVTSESR |
400:
GDNPDNTSQA | GDQEDSESSE | EDSLNTFSSS | ESQSTEEQAD | SESNESLSLS |
450:
EESQESAQDG | DSSSQEGLQS | QSASTESRSQ | ESQSEQDSRS | EEDSDSQDSS |
500:
RSKEESNSTG | SASSSEEDIR | PKNMEADSRK | LIVDAYHNKP | IGDQDDNDCQ |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Human
Mouse
Bovine
ELISA Kit for Mouse DMP-1
ELISA Kit for Mouse DMP-1
ELISA Kit for Mouse DMP-1
ELISA Kit for Mouse DMP-1
Polyclonal Antibody for Mouse DMP-1
Polyclonal Antibody for Mouse DMP-1
Polyclonal Antibody for Mouse DMP-1
Polyclonal Antibody for Mouse DMP-1
Monoclonal Antibody for Mouse DMP-1
Monoclonal Antibody for Mouse DMP-1
Monoclonal Antibody for Mouse DMP-1
Monoclonal Antibody for Mouse DMP-1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
Swiss Webster .
tissue :
Molar .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
strain :
129/SvJ .
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Spleen .
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Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6J .
tissue :
Head .
tissue :
Inner ear .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DISRUPTION PHENOTYPE